Cardiospecificity of -receptor blockade. A comparison of the relative potencies on cardiac and peripheral vascular -adrenoceptors of propranolol, of practolol and its ortho-substituted isomer, and of oxprenolol and its para-substituted isomer.

Acetanilides/pharmacology Action Potentials/drug effects Adrenergic beta-Antagonists/pharmacology Amino Alcohols/pharmacology Animals Anura Aorta Blood Circulation/drug effects Dogs Dose-Response Relationship, Drug Heart/drug effects Heart Atria/drug effects Heart Rate/drug effects In Vitro Techniques Injections, Intra-Arterial Injections, Intravenous Isomerism Isoproterenol/administration & dosage,antagonists & inhibitors Mesenteric Arteries Organ Specificity Oxprenolol/pharmacology Propranolol/pharmacology Rabbits Receptors, Adrenergic/drug effects Sciatic Nerve/physiology

Acetanilides Adrenergic beta-Antagonists Amino Alcohols Receptors, Adrenergic Oxprenolol Propranolol Isoproterenol