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PMID: 414259 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Mesolimbic dopamine neurons: effects of 6-hydroxydopamine-induced destruction and receptor blockade on drug-induced rotation of rats.

Psychopharmacology ·Vol. 55 ·No. 1 ·1977-11-24 ·Pages 35-41

Kelly PH, Moore KE

Abstract

Bilateral injections of 6-hydroxydopamine (6-OHDA) into the nucleus accumbens greatly reduced the dopamine content of this nucleus and the olfactory tubercle and blocked the ipsilateral rotation induced by amphetamine and methamphetamine in rats with unilateral 6-OHDA lesions of the caudate nucleus. In contrast, apomorphine-induced contralateral rotation was enhanced. Similar results were obtained when the destruction of forebrain noradrenergic neurons, normally produced by the nucleus accumbens 6-OHDA lesion, was prevented by desipramine (DMI) pretreatment. Microinjections of the dopamine receptor antagonist heloperidol into the nucleus accumbens did not spread to the olfactory tubercle, as assessed by the distribution of 3H-haloperidol, and blocked circling induced by amphetamine and apomorphine. Amphetamine-induced circling was less effectively blocked by haloperidol injected into the olfactory tubercle. These results suggest that activity at nucleus accumbens dopamine receptors can greatly affect circling behavior, perhaps by amplifying asymmetries of nigrostriatal activity.

MeSH Terms
Amphetamine/pharmacology Animals Apomorphine/pharmacology Behavior, Animal/drug effects Caudate Nucleus/drug effects Dextroamphetamine/pharmacology Haloperidol/pharmacology Hydroxydopamines/pharmacology Male Nucleus Accumbens/physiology Rats Receptors, Dopamine/physiology Septal Nuclei/physiology
Chemicals
Hydroxydopamines Receptors, Dopamine Amphetamine Haloperidol Apomorphine Dextroamphetamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kelly P H
Moore K E
References (31)
31 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00432814
Published
1977-11-24
Pages
35-41
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00432814 View journal details
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