Centric fusion, satellite DNA, and DNA polarity in mouse chromosomes.

Science (New York, N.Y.) ·Vol. 185 ·No. 4157 ·1974-09-27 ·Pages 1179-81

Lin MS, Davidson RL

Abstract

A fluorescent staining technique has demonstrated a contralateral arrangement of fluorescent spots in the centromeric region of mouse metacentric chromosomes which have resulted from centric fusion. The results suggest that centric fusion involves the maintenance of DNA polaritv through the centromere and that the thymidine-rich chain of satellite DNA in the centromeric region is associated with the same DNA chain in every mouse autosome.

MeSH Terms

Animals Bromodeoxyuridine/metabolism Cell Division/drug effects Cell Line Chromatids Chromosome Aberrations Chromosomes/analysis Crossing Over, Genetic DNA/analysis DNA Replication Female Fluorescent Dyes Male Mice Microscopy, Fluorescence Mitosis/drug effects Staining and Labeling/methods Thymidine/analysis

Chemicals

Fluorescent Dyes DNA Bromodeoxyuridine Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lin M S

Davidson R L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.185.4157.1179

Published

1974-09-27

Pages

1179-81

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.185.4157.1179 View journal details

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Centric fusion, satellite DNA, and DNA polarity in mouse chromosomes.

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