Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.

British journal of pharmacology ·Vol. 49 ·No. 2 ·1973-10-00 ·Pages 226-42

Palmer MA, Piper PJ, Vane JR

Abstract

1. Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.

MeSH Terms

Angiotensin II/pharmacology Animals Aorta Arachidonic Acids/pharmacology Arachis Aspirin/pharmacology Bradykinin/administration & dosage,pharmacology Guinea Pigs Half-Life Histamine Release In Vitro Techniques Indomethacin/pharmacology Injections, Intra-Arterial Linolenic Acids/pharmacology Lung/drug effects,metabolism Male Muscle Contraction/drug effects Oils Ovalbumin/pharmacology Particle Size Prostaglandins/metabolism Rabbits Rats Vasoconstrictor Agents/metabolism

Chemicals

Arachidonic Acids Linolenic Acids Oils Prostaglandins Vasoconstrictor Agents Angiotensin II Ovalbumin Aspirin Bradykinin Indomethacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Palmer M A

Piper P J

Vane J R

References (23)

23 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1973.tb08368.x

Published

1973-10-00

Pages

226-42

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1776376

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1973.tb08368.x PMC Full Text View journal details

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Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.

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