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PMID: 4128825 Published · ppublish English Journal Article

Antigenic components of group A arbovirus virions.

Journal of virology ·Vol. 12 ·No. 5 ·1973-11-00 ·Pages 1034-42

Dalrymple JM, Vogel SN, Teramoto AY, Russell PK

Abstract

Three group A arboviruses, Sindbis (SIN), western (WEE) and eastern equine encephalitis (EEE), were selectively degraded with a nonionic detergent to yield a core particle and a soluble envelope component. Antigenic analysis by using radioimmune precipitation techniques revealed marked antigenic similarity among the core particles of the three viruses. The soluble envelope component exhibited antigenic specificity similar to that of intact virions. A close relationship between SIN and WEE envelopes was shown, whereas EEE envelope antigen appeared antigenically specific. These data indicate that nucleocapsids of group A arboviruses contain an antigenic determinant common to the group; the envelope contains virus-specific antigens as well as antigens which relate members of a subgroup.

MeSH Terms
Amino Acids/metabolism Animals Antibody Specificity Antigens, Viral/analysis,isolation & purification Ascitic Fluid Brain/immunology Carbon Radioisotopes Cells, Cultured Centrifugation, Zonal Chick Embryo Cross Reactions Electrophoresis, Polyacrylamide Gel Encephalitis Virus, Western Equine/immunology Encephalitis Viruses/immunology Epitopes Mice Precipitin Tests RNA, Viral/analysis Rabbits/immunology Radioimmunoassay Sindbis Virus/immunology Tritium Uridine/metabolism
Chemicals
Amino Acids Antigens, Viral Carbon Radioisotopes Epitopes RNA, Viral Tritium Uridine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dalrymple J M
Vogel S N
Teramoto A Y
Russell P K
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.12.5.1034-1042.1973
Published
1973-11-00
Pages
1034-42
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356734
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.12.5.1034-1042.1973 PMC Full Text View journal details
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