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PMID: 4127828 Published · ppublish English Journal Article

The formation of synapses in reinnervated mammalian striated muscle.

The Journal of physiology ·Vol. 233 ·No. 3 ·1973-09-00 ·Pages 481-500

Bennett MR, McLachlan EM, Taylor RS

Abstract

1. The hemidiaphragm of the adult rabbit has a single band of end-plates running around the middle of the muscle. A study has been made of the formation of synapses during spontaneous reinnervation of this muscle, using histological, ultrastructural and electrophysiological techniques.2. Following spontaneous reinnervation, silver-stained nerve terminals were found in association with cholinesterase-stained end-plates only in the region of the muscle corresponding to the original innervation band.3. The regenerated nerve terminals were observed with the electronmicroscope in positions overlying or adjacent to the old synaptic folds.4. Spontaneous miniature end-plate potentials and evoked synaptic potentials were recorded only in the middle of the muscle fibres after reinnervation.5. The growth of the regenerating axons was not oriented towards the end-plate zone but followed muscle fibres and blood vessels in random directions.6. It is concluded that, in adult mammalian striated muscle, the old end-plate region is preferentially reinnervated as a consequence of some special property of the muscle fibre at this site.

MeSH Terms
Animals Axons/physiology Cholinesterases/analysis Diaphragm/innervation Electrophysiology Microscopy, Electron Muscles/blood supply,innervation Myofibrils/physiology Nerve Degeneration Nerve Endings Nerve Regeneration Neuromuscular Junction Rabbits Silver Staining and Labeling Synapses
Chemicals
Silver Cholinesterases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bennett M R
McLachlan E M
Taylor R S
References (44)
44 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1973.sp010319
Published
1973-09-00
Pages
481-500
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1350588
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1973.sp010319 PMC Full Text View journal details
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