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PMID: 4125701 Published · ppublish English Journal Article

Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.

The American journal of pathology ·Vol. 72 ·No. 3 ·1973-09-00 ·Pages 521-40

Shelburne JD, Arstila AU, Trump BF

Abstract

Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.

MeSH Terms
Animals Butyrates/administration & dosage,pharmacology Cyclic AMP/administration & dosage,pharmacology Female Glucagon/pharmacology Injections, Intraperitoneal Liver/cytology,drug effects Liver Glycogen/metabolism Microscopy, Electron Mitochondria Phagocytosis/drug effects Rats Sodium Chloride/pharmacology Staining and Labeling Time Factors
Chemicals
Butyrates Liver Glycogen Sodium Chloride Glucagon Cyclic AMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shelburne J D
Arstila A U
Trump B F
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43 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1973-09-00
Pages
521-40
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1904032
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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