The effect of phospholipids on anaphylactic histamine release.

British journal of pharmacology ·Vol. 46 ·No. 4 ·1972-12-00 ·Pages 741-52

Mongar JL, Svec P

Abstract

1. Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive.2. PS greatly increases the rate of antigen-induced histamine release and only slightly prolongs the duration of the release process.3. PS shows a concentration-dependent effect over the range 1-10 mug/ml. At 10 mug/ml it is active over a wide range of antigen concentrations.4. Calcium ions are necessary for the potentiation by PS of antigen-induced histamine release from rat peritoneal cells.

MeSH Terms

Animals Antigens Calcium/administration & dosage,pharmacology Female Guinea Pigs Histamine Release/drug effects Hypersensitivity, Immediate In Vitro Techniques Lung/metabolism Male Mast Cells/immunology Mesentery/metabolism Peritoneum/metabolism Phosphatidylcholines/pharmacology Phosphatidylethanolamines/pharmacology Phospholipids/metabolism,pharmacology Rats Time Factors

Chemicals

Antigens Phosphatidylcholines Phosphatidylethanolamines Phospholipids Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mongar J L

Svec P

References (16)

16 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1972.tb06899.x

Published

1972-12-00

Pages

741-52

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1666372

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1972.tb06899.x PMC Full Text View journal details

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