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PMID: 4119586 Published · ppublish English Journal Article

Immunodeviation by passive antibody, an expression of selective immunodepression. II. Action of guinea pig IgG1 and IgG2 anticarrier antibodies.

The Journal of experimental medicine ·Vol. 137 ·No. 2 ·1973-02-01 ·Pages 265-74

Vuagnat P, Neveu T, Voisin GA

Abstract

The effect of passively administered IgG1 and IgG2 anticarrier antibodies on the IgG1 and IgG2 antihapten response has been studied. Guinea pigs were immunized with dinitrophenylated bovine gamma globulin mixed with purified IgG1 or IgG2 antihuman gamma globulin antibodies, i.e., antibodies directed against a limited range of the carrier determinants. Humoral IgG1 and IgG2 anti-DNP antibody contents were assayed at weekly intervals and 4 to 10 days after a booster injection of antigen in saline given on the 12th wk. The main finding was the sustained suppressive effect of passive IgG1 anti-carrier antibodies on the active IgG1 antihapten response. This result is compared with the enhancing effect of passive IgG1 antihapten antibodies and is discussed in the light of T cell-B cell and hapten-carrier relationships, leading to the proposal of a regulatory function of the Fc portion of the IgG1 anticarrier antibody, combined with the antigen, on the T cell.

MeSH Terms
Animals Antibodies Antigens Carrier Proteins Epitopes Guinea Pigs Haptens Hypersensitivity, Delayed Immunity, Maternally-Acquired Immunoglobulin G Immunosuppression Therapy Serum Albumin, Bovine gamma-Globulins
Chemicals
Antibodies Antigens Carrier Proteins Epitopes Haptens Immunoglobulin G gamma-Globulins Serum Albumin, Bovine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vuagnat P
Neveu T
Voisin G A
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34 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.137.2.265
Published
1973-02-01
Pages
265-74
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139495
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.137.2.265 PMC Full Text View journal details
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