Isolation of RNA virus from papillary tumors of the human renal pelvis.

Science (New York, N.Y.) ·Vol. 179 ·No. 4071 ·1973-01-26 ·Pages 393-5

Elliott AY, Fraley EE, Cleveland P, Castro AE, Stein N

Abstract

Virus particles were detected by electron microscopy in three papillary cancers of the human renal pelvis. Similar particles were seen in cells from all three tumors in primary culture. An RNA virus was isolated from these tumors. The serum of tumor patients contains neutralizing antibodies against virus isolated from two of the tumors. Initial studies suggest that this agent is not a known human RNA virus.

MeSH Terms

Adult Antibodies, Viral/analysis Carbon Isotopes Carcinoma, Transitional Cell/microbiology Cells, Cultured Centrifugation, Density Gradient Cytopathogenic Effect, Viral Fibroblasts Humans Kidney Kidney Neoplasms/microbiology Kidney Pelvis Male Microscopy, Electron Neutralization Tests Orotic Acid/metabolism RNA Viruses/enzymology,immunology,isolation & purification,metabolism RNA-Directed DNA Polymerase/analysis Retroviridae/isolation & purification Templates, Genetic Testis

Chemicals

Antibodies, Viral Carbon Isotopes Orotic Acid RNA-Directed DNA Polymerase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Elliott A Y

Fraley E E

Cleveland P

Castro A E

Stein N

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.179.4071.393

Published

1973-01-26

Pages

393-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.179.4071.393 View journal details

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Isolation of RNA virus from papillary tumors of the human renal pelvis.

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