Home LiteratureArticle Details
PMID: 4118891 Published · ppublish English Journal Article

Cerebellar alterations in the weaver mouse.

The Journal of cell biology ·Vol. 56 ·No. 2 ·1973-02-00 ·Pages 478-86

Hirano A, Dembitzer HM

Abstract

The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed. Unexpectedly, however, the dendritic spines of the Purkinje cells which, in normal animals, are the postsynaptic mates of the parallel fibers, were present. Furthermore, their essential morphology and their staining reactions were indistinguishable from those of the Purkinje cell dendritic spines in normal animals. Possible mechanisms of development are discussed.

MeSH Terms
Acetates Animals Axons/cytology Bismuth Cerebellar Cortex/cytology Cerebellum/cytology Dendrites/cytology Ethanol Histological Techniques Iodides Mice Phosphotungstic Acid Purkinje Cells/cytology Staining and Labeling Synaptic Vesicles/cytology Uranium
Chemicals
Acetates Iodides Phosphotungstic Acid Ethanol Uranium Bismuth
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hirano A
Dembitzer H M
References (25)
25 references, click to expand
  1. A comparison of the mode of termination of the hippocampal and hypothalamic afferents to the septal nuclei as revealed by electron microscopy of degeneration.
    Exp Brain Res. 1969;7(4):317-43 PMID: 5799435
  2. Synaptogenesis in the chick embryo spinal cord.
    Nat New Biol. 1972 Jan 26;235(56):126-8 PMID: 4501198
  3. The primate cerebellar cortex: a Golgi and electron microscopic study.
    Prog Brain Res. 1967;25:174-225 PMID: 4866553
  4. The postnatal development of the synapse: a morphological approach utilizing synaptosomes. I. General features.
    Z Zellforsch Mikrosk Anat. 1970;111(2):179-94 PMID: 5488296
  5. Proceedings of the anatomical society of great britain and ireland.
    J Anat. 1966 Jul;100(Pt 3):683-706 PMID: 17103499
  6. Staggerer, a new mutation in the mouse affecting the cerebellum.
    Science. 1962 Aug 24;137(3530):610-2 PMID: 13912552
  7. Developmental mechanism for changes in cerebellum of "staggerer" mouse, a neurological mutant of genetic origin.
    Neurology. 1972 Jul;22(7):743-54 PMID: 4673255
  8. Persistence of post-synaptic membrane thickenings after degeneration of olfactory nerves.
    Brain Res. 1969 Nov;16(1):277-81 PMID: 5348856
  9. Fine structure of synapses in the dorsal nucleus of the lateral geniculate body of normal and blinded rats.
    Z Zellforsch Mikrosk Anat. 1967;76(1):116-46 PMID: 5340225
  10. Structural modulations of plasmalemmal vesicles.
    J Cell Biol. 1968 Jun;37(3):633-49 PMID: 11905197
  11. Fine structural and cytochemical analysis of the staining of synaptic junctions with phosphotungstic acid.
    J Ultrastruct Res. 1968 Mar;22(5):361-75 PMID: 4173151
  12. The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells.
    Brain Res. 1971 Nov;34(1):73-97 PMID: 4330971
  13. Electron microscopy of experimental degeneration in the avian optic tectum.
    J Anat. 1962 Jul;96(Pt 3):309-316.5 PMID: 17105129
  14. The cytochemistry of synaptic densities. I. An analysis of the bismuth lodide impregnation method.
    J Ultrastruct Res. 1971 Jan;34(1):103-22 PMID: 4099757
  15. Staggerer, a neurological murine mutant. An electron microscopic study of the cerebellar cortex in the adult.
    Neurology. 1968 Nov;18(11):1093-100 PMID: 5751915
  16. The synaptic organization of the malformed cerebellum induced by perinatal infection with the feline panleukopenia virus (PLV). II. The Purkinje cell and its afferents.
    J Neuropathol Exp Neurol. 1971 Oct;30(4):557-70 PMID: 5135012
  17. ELECTRON MICROSCOPICAL STUDIES OF THE SYNAPSE IN THE DEVELOPING CHICK SPINAL CORD.
    Z Zellforsch Mikrosk Anat. 1964 Apr 9;62:356-62 PMID: 14218148
  18. An unusual relationship between glial cells and neuronal dendrites in olfactory bulbs of Desmodus rotundus.
    Brain Res. 1972 Jan 28;36(2):404-8 PMID: 5009644
  19. The onset of synapse formation in spinal cord cultures as studied by electron microscopy.
    Brain Res. 1967 Dec;6(4):728-49 PMID: 6080223
  20. Synaptic morphology in the normal and degenerating nervous system.
    Int Rev Cytol. 1966;19:111-82 PMID: 5337764
  21. Thiophen induced granule cell necrosis in the rat cerebellum. An electron microscopic study.
    Exp Brain Res. 1968;6(1):49-68 PMID: 5721756
  22. The organization of paramembranous densities during postnatal maturation of synaptic junctions in the cerebral cortex.
    Exp Neurol. 1972 Mar;34(3):383-93 PMID: 4112310
  23. Synapses on the Purkinje cell spines in the mouse. An electronmicroscopic study.
    Brain Res. 1967 May;5(1):15-30 PMID: 6035937
  24. The molecular layer of the adult cat cerebellar cortex after lesion of the parallel fibers: an optic and electron microscope study.
    Brain Res. 1969 Dec;16(2):307-23 PMID: 4188175
  25. Fine structural aspects of the synaptic organization of the spinal trigeminal nucleus (pars interpolaris) of the cat.
    Brain Res. 1971 Jan 22;25(2):265-87 PMID: 4925762
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.56.2.478
Published
1973-02-00
Pages
478-86
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2108902
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.56.2.478 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2