Detergent effects on a reverse transcriptase activity and on inhibition by rifamycin derivatives.

Science (New York, N.Y.) ·Vol. 178 ·No. 4060 ·1972-11-03 ·Pages 505-7

Thompson FM, Libertini LJ, Joss UR, Calvin M

Abstract

A reverse transcriptase activity, extracted from virus-transformed cells, is activated by very low concentrations of nonionic detergents. These same detergents also significantly reduce the effectiveness of certain rifamycin derivatives as inhibitors of the polymerase activity when the detergents are present at micelle-forming concentrations.

MeSH Terms

Cell Transformation, Neoplastic Cells, Cultured Detergents/pharmacology Enzyme Activation RNA-Directed DNA Polymerase Reverse Transcriptase Inhibitors Rifamycins/antagonists & inhibitors,pharmacology

Chemicals

Detergents Reverse Transcriptase Inhibitors Rifamycins RNA-Directed DNA Polymerase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thompson F M

Libertini L J

Joss U R

Calvin M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.178.4060.505

Published

1972-11-03

Pages

505-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.178.4060.505 View journal details

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Detergent effects on a reverse transcriptase activity and on inhibition by rifamycin derivatives.

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