Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays.

The Journal of experimental medicine ·Vol. 136 ·No. 3 ·1972-09-01 ·Pages 650-5

Wernet P, Feizi T, Kunkel HG

Abstract

The complement-mediated cytotoxicity assay has been used to demonstrate surface immunoglobulin determinants on human peripheral blood lymphocytes. In two individuals with monoclonal serum IgM components, idiotypic antisera demonstrated similar components on a significant proportion of the peripheral blood lymphocytes.

MeSH Terms

Antilymphocyte Serum Cell Membrane/immunology Cytotoxicity Tests, Immunologic Epitopes/analysis Fluorescent Antibody Technique Humans Immunoglobulins/analysis In Vitro Techniques Lymphocytes/immunology

Chemicals

Antilymphocyte Serum Epitopes Immunoglobulins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wernet P

Feizi T

Kunkel H G

References (11)

11 references, click to expand

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Nat New Biol. 1972 May 3;237(70):18-20 PMID: 4113235
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.136.3.650

Published

1972-09-01

Pages

650-5

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139263

Subset

External Links

PubMed source DOI: 10.1084/jem.136.3.650 PMC Full Text View journal details

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Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays.

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