Sites of alpha-fetoprotein synthesis.

The New England journal of medicine ·Vol. 285 ·No. 25 ·1971-12-16 ·Pages 1436-7

Gitlin D

Abstract

暂无摘要

Keywords

Alpha Fetoproteins--analysis Biology Blood Proteins Embryo Fetal Membranes Fetus Hemic System Physiology Pregnancy Reproduction

MeSH Terms

Alpha-Globulins/biosynthesis Animals Digestive System/metabolism Embryo, Mammalian Embryo, Nonmammalian Extraembryonic Membranes/metabolism Fetal Proteins/biosynthesis Humans Liver/metabolism Rats Sharks

Chemicals

Alpha-Globulins Fetal Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gitlin D

Other Abstracts

eng

New information on alpha fetoprotein (AFP) sites of synthesis are presented in this letter to the editor. Traces of AFP were synthesized by not only the human yolk sac and liver but also, in 6/9 human embryos and fetuses studied, by the gastrointestinal tract. Also, sharks synthesize an AFP similar to that of the human in molecular size and electrophoretic mobility. Although small amounts of AFP are synthesized by sharks in the liver, the greatest site of synthesis is actually the stomach, with smaller amounts synthesized in the intestinal mucosa

no synthesis was observed in the shark yolk sac. Thus it appears that early in evolution the site of synthesis of AFP was mainly in the gastrointestinal tract and that during evolution 2 outgrowths of the entoderm (the liver and yolk sac) became the major sites of AFP synthesis

in birds the synthesis seems to be restricted to the yolk sac, with only traces found in the gastrointestinal tract.

Article Info

Journal

The New England journal of medicine

Abbr.

N Engl J Med

ISSN

0028-4793

DOI

10.1056/NEJM197112162852517

Published

1971-12-16

Pages

1436-7

Language

English

Region

United States

NLM ID

0255562

Subset

External Links

PubMed source DOI: 10.1056/NEJM197112162852517 View journal details

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Sites of alpha-fetoprotein synthesis.

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