Inhibition of nucleotidyl transferase enzymes by metal ions in combination with 5-amino-1-formylisoquinoline thiosemicarbazone.

Cations, Divalent Chelating Agents/pharmacology Copper/pharmacology DNA Polymerase I/antagonists & inhibitors DNA Polymerase II/metabolism DNA-Directed RNA Polymerases/antagonists & inhibitors Edetic Acid/pharmacology Iron/pharmacology Isoquinolines/pharmacology Nucleic Acid Synthesis Inhibitors RNA Polymerase II/antagonists & inhibitors RNA Polymerase III/antagonists & inhibitors Sea Urchins/enzymology Thiosemicarbazones/pharmacology

Cations, Divalent Chelating Agents Isoquinolines Nucleic Acid Synthesis Inhibitors Thiosemicarbazones 5-amino-1-formylisoquinoline thiosemicarbazone Copper Edetic Acid Iron RNA Polymerase II DNA-Directed RNA Polymerases RNA Polymerase III DNA Polymerase I DNA Polymerase II