Interaction between prostaglandins E and F given intradermally in the rat.

British journal of pharmacology ·Vol. 41 ·No. 3 ·1971-03-00 ·Pages 507-12

Crunkhorn P, Willis AL

Abstract

1. Increases in permeability observed after intradermal injection of prostaglandins PGE(1) or PGE(2) (0.1 mug) into rats were greatly reduced when they were given in admixture with PGF(2alpha). This effect was not seen with PGF(1alpha) at doses of 0.5-1 mug.2. Effects of the histamine releasing agent compound 48/80 (25 ng) were inhibited by PGF(2alpha) (0.5 mug) but not by PGF(1alpha) (0.5 mug).3. Responses to histamine (1 mug), 5-hydroxytryptamine (0.1 mug) and bradykinin (1 mug), which have a direct action on the microvasculature, were not significantly altered by PGF(2alpha) (0.5 mug).4. It is concluded that PGF(2alpha) probably acts by interfering with the release of mast cell histamine by PGE(1), PGE(2) and compound 48/80.

MeSH Terms

Animals Bradykinin/pharmacology Capillary Permeability/drug effects Female Histamine/pharmacology Histamine Release/drug effects Injections, Intradermal Prostaglandin Antagonists Prostaglandins/administration & dosage Rats Serotonin/pharmacology p-Methoxy-N-methylphenethylamine/pharmacology

Chemicals

Prostaglandin Antagonists Prostaglandins Serotonin p-Methoxy-N-methylphenethylamine Histamine Bradykinin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Crunkhorn P

Willis A L

References (11)

11 references, click to expand

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The prostaglandins: a family of biologically active lipids.
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Br J Pharmacol. 1969 May;36(1):216P-217P PMID: 5768125
Cutaneous reactions to intradermal prostaglandins.
Br J Pharmacol. 1971 Jan;41(1):49-56 PMID: 4396130
Further studies on the preparation, purification and nature of irin.
J Physiol. 1959 May 19;146(2):255-94 PMID: 13655231
EFFECT OF MECHANICAL STIMULATION ON RABBITS' EYES: RELEASE OF ACTIVE SUBSTANCE IN ANTERIOR CHAMBER PERFUSATES.
J Physiol. 1965 Feb;176:378-408 PMID: 14289827
THE ORIGIN OF OXYGEN INCORPORATED DURING THE BIOSYNTHESIS OF PROSTAGLANDIN E-1.
Biochem Biophys Res Commun. 1965 Apr 23;19:279-82 PMID: 14317389
THE BIOSYNTHESIS OF PROSTAGLANDIN E1 STUDIED WITH SPECIFICALLY 3H-LABELLED 8,11,14-EICOSATRIENOIC ACIDS.
Acta Chem Scand. 1965;19:534-5 PMID: 14298283
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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1971.tb08048.x

Published

1971-03-00

Pages

507-12

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1702861

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1971.tb08048.x PMC Full Text View journal details

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Interaction between prostaglandins E and F given intradermally in the rat.

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