Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals.

Histochemistry ·Vol. 53 ·No. 1 ·1977-07-18 ·Pages 35-41

Helmstaedter V, Taugner C, Feurle GE, Forssmann WG

Abstract

Antibodies against synthetic bovine neurotensin were raised in rabbits and used to demonstrate neurotensin-immunreactive cells by immunohistochemical methods. In the jejunum and ileum of all species investigated (man, dog, monkey, cat, rabbit, sheep, rat, mouse, hamster, chinese hamster, gerbil, pig and guinea pig) cells were present in the mucosa, which reacted specifically with antineurotensin serum using the indirect immunofluorescence and peroxidase-antiperoxidase methods. In the monkey Tupaia the distribution of neurotensin-immunoreactive cells was examined by investigating serial sections through the entire gastro-entero-pancreatic (GEP) endocrine system, again showing most neurotensin-immunoreactive cells in the jejunum and ileum. The functional role of the presence of neurotensin immunoreactivity in the gut is discussed.

MeSH Terms

Animals Cats Cricetinae Dogs Duodenum/analysis Fluorescent Antibody Technique Gerbillinae Guinea Pigs Haplorhini Humans Ileum/analysis Immunoenzyme Techniques Intestinal Mucosa/analysis Intestine, Small/analysis Jejunum/analysis Mice Neurotensin/analysis Rabbits Rats Sheep Swine

Chemicals

Neurotensin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Helmstaedter V

Taugner C

Feurle G E

Forssmann W G

References (14)

14 references, click to expand

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Article Info

Journal

Histochemistry

Abbr.

Histochemistry

ISSN

0301-5564

DOI

10.1007/BF00511208

Published

1977-07-18

Pages

35-41

Language

English

Region

Germany

NLM ID

0411300

Subset

External Links

PubMed source DOI: 10.1007/BF00511208

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Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals.

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