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PMID: 4082924 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A quantitative and ultrastructural study of substantia nigra and nucleus centralis superior in Alzheimer's disease.

Acta neuropathologica ·Vol. 68 ·No. 3 ·1985-00-00 ·Pages 218-23

Tabaton M, Schenone A, Romagnoli P, Mancardi GL

Abstract

In four patients with presenile Alzheimer's disease (AD) and three age-matched controls a quantitative study of neurons and neurofibrillary tangles (NFT) in the substantia nigra (SN) and nucleus centralis superior (NCS) was performed. A significant neuronal loss, similar in both nuclei, was found in AD cases, while the incidence of NFT was remarkably higher in NCS. Moreover, no significant correlation between neuronal loss and number of NFT was detected. An electron-microscopic study revealed that the subcortical NFT in NCS are made up of paired helical filaments in spite of their globose round shape.

MeSH Terms
Aged Alzheimer Disease/pathology Cerebellar Nuclei/pathology Female Humans Male Middle Aged Neurofibrils/pathology,ultrastructure Neurons/pathology Substantia Nigra/pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tabaton M
Schenone A
Romagnoli P
Mancardi G L
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27 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00690198
Published
1985-00-00
Pages
218-23
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00690198 View journal details
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