The reaction of the cancerostatic CCNU with the catalytic site of transglutaminase.

Cancer biochemistry biophysics ·Vol. 4 ·No. 1 ·1979-00-00 ·Pages 33-6

Tarantino A, Thompson P

Abstract

The experiments in this paper show for the first time that CCNU, a nitrosourea, inhibits transglutaminase (an enzyme believed to be involved in tissue proliferation) on account of its cyclohexyl-isocyanate moiety.

MeSH Terms

Animals Binding Sites Cyanates/pharmacology Guinea Pigs Kinetics Liver/enzymology Lomustine/pharmacology Nitrosourea Compounds/pharmacology Protein Binding gamma-Glutamyltransferase/antagonists & inhibitors,metabolism

Chemicals

Cyanates Nitrosourea Compounds Lomustine gamma-Glutamyltransferase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tarantino A

Thompson P

Article Info

Journal

Cancer biochemistry biophysics

Abbr.

Cancer Biochem Biophys

ISSN

0305-7232

Published

1979-00-00

Pages

33-6

Language

English

Region

England

NLM ID

7506524

Subset

External Links

PubMed source

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The reaction of the cancerostatic CCNU with the catalytic site of transglutaminase.

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