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PMID: 4043223 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite.

European journal of pharmacology ·Vol. 114 ·No. 1 ·1985-08-07 ·Pages 93-6

Shirasaki Y, Su C

Abstract

Sodium nitroprusside (3-100 nM) and sodium nitrite (0.03-1 mM) caused relaxation of the rat aortic ring segments precontracted by norepinephrine. The relaxation was significantly augmented by removal of endothelium, and this augmentation was greater in the aorta from spontaneously hypertensive rats (SHR) than Wistar Kyoto rats (WKY). The mechanism remains unknown but such augmentation may be clinically favorable to the use of nitrovasodilators.

MeSH Terms

Adenosine/pharmacology Animals Aorta, Thoracic/drug effects,physiology Endothelium/physiology Ferricyanides/pharmacology In Vitro Techniques Isoproterenol/pharmacology Male Nitrites/pharmacology Nitroprusside/pharmacology Potassium Chloride/pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Sodium Nitrite/pharmacology Vasodilation/drug effects

Chemicals

Ferricyanides Nitrites Nitroprusside Potassium Chloride Adenosine Isoproterenol Sodium Nitrite

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Shirasaki Y

Su C

Article Info

Journal

European journal of pharmacology

Abbr.

Eur J Pharmacol

ISSN

0014-2999

DOI

10.1016/0014-2999(85)90527-8

Published

1985-08-07

Pages

93-6

Language

English

Region

Netherlands

NLM ID

1254354

Subset

External Links

PubMed source DOI: 10.1016/0014-2999(85)90527-8 View journal details

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Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite.

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