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PMID: 4041541 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Capacitative transients in voltage-clamped epithelia.

Biophysical journal ·Vol. 48 ·No. 3 ·1985-09-00 ·Pages 519-23

Garcia-Diaz JF, Essig A

Abstract

In voltage-clamped epithelia the cell membrane potential transient during a + 10-mV transepithelial pulse conforms to the expected behavior for a series combination of two linear resistance-capacitance (RC) circuits. The evolution of the cell potential is characterized by a single time constant with values of 30-130 ms in frog skin and Necturus gallbladder. These observations have important consequences for the measurement of cell membrane resistance ratios and the interpretation of current-voltage relations.

MeSH Terms
Amiloride/pharmacology Animals Cell Membrane/physiology Electric Conductivity/drug effects Epithelium/physiology Gallbladder/physiology Mathematics Membrane Potentials Models, Biological Necturus Ranidae Skin Physiological Phenomena
Chemicals
Amiloride
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Garcia-Diaz J F
Essig A
References (11)
11 references, click to expand
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  7. Contribution of junctional conductance to the cellular voltage-divider ratio in frog skins.
    Pflugers Arch. 1983 Dec;399(4):336-41 PMID: 6607457
  8. Electrophysiology of Necturus urinary bladder: II. Time-dependent current-voltage relations of the basolateral membranes.
    J Membr Biol. 1984;79(3):257-69 PMID: 6471095
  9. Influence of cellular and paracellular conductance patterns on epithelial transport and metabolism.
    Biophys J. 1982 May;38(2):143-52 PMID: 6284264
  10. Anomalous impedance, a phenomenological property of time-variant resistance. An analytic review.
    Biophys J. 1961 Mar;1:353-72 PMID: 13768450
  11. Voltage-dependent K conductance at the apical membrane of Necturus gallbladder.
    Biophys J. 1983 Sep;43(3):269-78 PMID: 6313084
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(85)83807-8
Published
1985-09-00
Pages
519-23
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1329365
Subset
IM
Grants
NIADDK NIH HHS · AM 29968 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(85)83807-8 PMC Full Text View journal details
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