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PMID: 4029952 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inversion (14)(q12qter) or (q11.2q32.3): the most frequently acquired rearrangement in lymphocytes.

Human genetics ·Vol. 71 ·No. 1 ·1985-00-00 ·Pages 19-21

Aurias A, Couturier J, Dutrillaux AM, Dutrillaux B, Herpin F, Lamoliatte E, Lombard M, Muleris M, Paravatou M, Prieur M

Abstract

In a large study of chromosome rearrangements occurring in human lymphocytes from normal subjects, inv (14)(q12qter) or (q11.2q32.3) is found to be the most frequent, affecting 0.15% of mitoses. The same inversion is observed in the lymphocytes of the chimpanzee, indicating the ancestry of this inversion. It is not induced by ionizing radiations, and its frequency may be increased in Fanconi anemia, but not in ataxia telangiectasia. It may represent one of the steps of the process of leukemogenesis.

MeSH Terms
Animals Ataxia Telangiectasia/genetics Chromosome Banding Chromosome Inversion Chromosomes, Human, 13-15 Fanconi Anemia/genetics Humans Karyotyping Lymphocytes/radiation effects,ultrastructure Pan troglodytes Species Specificity
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Aurias A
Couturier J
Dutrillaux A M
Dutrillaux B
Herpin F
Lamoliatte E
Lombard M
Muleris M
Paravatou M
Prieur M
References (10)
10 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00295660
Published
1985-00-00
Pages
19-21
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00295660 View journal details
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