Inducible phenotypic multidrug resistance in the fungus Mucor racemosus.
The dimorphic fungus Mucor racemosus exhibited a single-step, inducible resistance to cycloheximide, trichodermin, and amphotericin B. Cells adapted to inhibitory levels of the antibiotics after 12 to 40 h. The adaptation involved all the cells in the population and was not the result of the selection of resistant mutants. Adaptation to one drug provided cross resistance to other, dissimilar drugs. Resistance was lost within several generations of growth in the absence of the inhibitors.
17 references, click to expand
-
Development of strains of Cryptococcus neoformans resistant to nystatin, amphotericin B, trichomycin and polymyxin B.Acta Pathol Microbiol Scand. 1968;73(4):572-82 PMID: 4301525
-
THE EFFECT OF 5-FLUORODEOXYURIDINE ON GENETIC REPLICATION AND MITOTIC CROSSING OVER IN SYNCHRONIZED CULTURES OF USTILAGO MAYDIS.Genetics. 1964 Nov;50:1009-17 PMID: 14239766
-
Antimicrobial agents. VI. Antimycotic activity and problems of resistance.Folia Microbiol (Praha). 1970;15(4):314-7 PMID: 5475121
-
Quantitative evaluation of the antifungal properties of cycloheximide.Antimicrob Agents Chemother. 1972 Mar;1(3):177-84 PMID: 5065214
-
Transient inhibition by cycloheximide of protein synthesis in cultured plant cell suspensions: a dose response paradox.Biochem Biophys Res Commun. 1973 Feb 20;50(4):1075-80 PMID: 4690848
-
Antimicrobial agents. 28. Inducible resistance in species of the genus Candida.Folia Microbiol (Praha). 1973;18(4):304-7 PMID: 4753342
-
Antimicrobial agents. XIX. Detoxication mechanism of some strains of Candida albicans.Folia Microbiol (Praha). 1973;18(6):522-3 PMID: 4590570
-
On the mechanism of adaptation to protein synthesis inhibitors by Tetrahymena. Facilitation, cross adaptation, and resensitization.J Cell Biol. 1974 Sep;62(3):707-16 PMID: 4853453
-
The effect of the herbicide 2,4,5 trichlorophenoxy acetic acid (245T) on the growth and metabolism of Tetrahymena pyriformis.J Cell Physiol. 1975 Apr;85(2 Pt 1):331-8 PMID: 804490
-
Adaptation to cycloheximide: in vitro studies with filamentous fungi.Can J Microbiol. 1975 Sep;21(9):1413-9 PMID: 1182615
-
Location of protein synthesis during morphogenesis of Mucor racemosus.J Bacteriol. 1978 Jan;133(1):399-400 PMID: 618844
-
Adaptational origin of some purine-analogue resistant phenotypes in cultured mammalian cells.Mutat Res. 1978 Feb;49(2):275-96 PMID: 625302
-
Resistance of selected saprobic and zoopathogenic fungi to cycloheximide.J Gen Microbiol. 1978 Mar;105(1):127-34 PMID: 632807
-
Unstable, non-mutational expression of resistance to the thymidine analogue, trifluorothymidine in CHO cells.Mutat Res. 1979 Apr;60(2):207-13 PMID: 111115
-
Population changes induced in Candida albicans by nalidixic acid.Mycopathologia. 1979 Sep 17;68(2):105-20 PMID: 386130
-
Genetic and adaptive differences in the expression of drug resistance in hybrid cells.Somatic Cell Genet. 1979 Nov;5(6):793-808 PMID: 545725
-
An analysis of the recovery of tetrahymena from effects of cycloheximide.J Cell Physiol. 1970 Aug;76(1):55-63 PMID: 4919262
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