Krabbe disease: increased incidence in a highly inbred community.

American journal of medical genetics ·Vol. 21 ·No. 4 ·1985-08-00 ·Pages 765-70

Zlotogora J, Regev R, Zeigler M, Iancu TC, Bach G

Abstract

Krabbe disease (globoid cell leukodystrophy) was found with very high incidence (6/1,000 live births) in a large Druze kindred in Israel. The clinical data on 12 of the affected children demonstrated clinical variability even though these children are homozygous for the same mutation by descent from a common ancestor.

MeSH Terms

Age Factors Galactosylceramidase/deficiency Humans Inbreeding Israel Leukodystrophy, Globoid Cell/epidemiology,genetics Pedigree

Chemicals

Galactosylceramidase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Zlotogora J

Regev R

Zeigler M

Iancu T C

Bach G

Article Info

Journal

American journal of medical genetics

Abbr.

Am J Med Genet

ISSN

0148-7299

DOI

10.1002/ajmg.1320210420

Published

1985-08-00

Pages

765-70

Language

English

Region

United States

NLM ID

7708900

Subset

External Links

PubMed source DOI: 10.1002/ajmg.1320210420

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