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PMID: 4022769 Published · ppublish English Journal Article

A highly polymorphic region 3' to the human type II collagen gene.

Nucleic acids research ·Vol. 13 ·No. 13 ·1985-07-11 ·Pages 4613-22

Stoker NG, Cheah KS, Griffin JR, Pope FM, Solomon E

Abstract

We have characterised a highly polymorphic region 1.3kb downstream of the human Type II collagen gene. It consists of a highly AT-rich tandem repetitive region (minisatellite) approximately 650bp long. Two alleles had been observed previously, differing in size by approximately 300bp. When this region was cloned from four unrelated individuals carrying the larger allele, DNA sequence data identified three alleles, suggesting far higher polymorphism than was originally supposed. This minisatellite was shown to be present in a single copy in the human genome, and to have arisen after the divergence of Old and New World monkeys.

MeSH Terms
Alleles Chromosome Deletion Collagen/genetics Humans Polymorphism, Genetic RNA, Messenger/analysis Repetitive Sequences, Nucleic Acid
Chemicals
RNA, Messenger Collagen
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Stoker N G
Cheah K S
Griffin J R
Pope F M
Solomon E
References (33)
33 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.13.4613
Published
1985-07-11
Pages
4613-22
Language
English
Region
England
NLM ID
0411011
PMCID
PMC321815
Subset
IM
Databases
GENBANK
X02670
External Links
PubMed source DOI: 10.1093/nar/13.13.4613 PMC Full Text View journal details
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