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PMID: 4009196 Published · ppublish English Case Reports Journal Article

Levodopa and melanoma: three cases and review of literature.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 48 ·No. 6 ·1985-06-00 ·Pages 585-8

Rampen FH

Abstract

Three patients are reported who developed a melanoma while taking levodopa for Parkinson's disease. There were two cutaneous melanomas and one metastatic melanoma with occult primary. The literature on the association of Parkinson's disease, levodopa therapy and melanoma is reviewed. The capacity of levodopa to induce melanomas and its alleged adverse effect on the clinical course of the disease are questioned.

MeSH Terms
Aged Female Humans Levodopa/adverse effects Male Melanoma/chemically induced,complications,secondary Parkinson Disease/complications,drug therapy Skin Neoplasms/chemically induced,complications
Chemicals
Levodopa
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rampen F H
References (13)
13 references, click to expand
  1. Multiple primary melanoma following administration of levodopa.
    Arch Pathol. 1972 Jun;93(6):556-61 PMID: 5025039
  2. Levodopa and malignant melanoma.
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  3. Levodopa and melanoma.
    Neurology. 1974 Apr;24(4):340-3 PMID: 4856355
  4. L-dopa: selective toxicity for melanoma cells in vitro.
    Science. 1977 Jul 29;197(4302):468-9 PMID: 877570
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    J Neurol. 1977 Jun 13;215(3):221-4 PMID: 69691
  6. Epidermotropically metastatic malignant melanoma. Differentiating malignant melanoma metastatic to the epidermis from malignant melanoma primary in the epidermis.
    Arch Dermatol. 1978 Jan;114(1):67-9 PMID: 619785
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    JAMA. 1978 Aug 11;240(6):554-5 PMID: 671667
  8. [Connection between levodopa therapy and malignant tumors].
    Lakartidningen. 1979 Jan 31;76(5):316-7 PMID: 759779
  9. Levodopa and melanoma.
    JAMA. 1979 Mar 2;241(9):883-4 PMID: 762862
  10. Levodopa administration and multiple primary cutaneous melanomas.
    Arch Dermatol. 1980 Sep;116(9):1041-44 PMID: 7416757
  11. Uveal malignant melanoma and levodopa therapy in Parkinson's disease.
    Ophthalmology. 1982 Dec;89(12):1464-6 PMID: 7162789
  12. Malignant melanoma and levodopa.
    Cutis. 1984 Jun;33(6):572-4 PMID: 6744949
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    JAMA. 1984 Aug 24-31;252(8):1011-2 PMID: 6748203
Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
DOI
10.1136/jnnp.48.6.585
Published
1985-06-00
Pages
585-8
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC1028378
Subset
IM
External Links
PubMed source DOI: 10.1136/jnnp.48.6.585 PMC Full Text View journal details
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