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PMID: 400782 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Suppression of the DnaA phenotype by mutations in the rpoB cistron of ribonucleic acid polymerase in Salmonella typhimurium and Escherichia coli.

Journal of bacteriology ·Vol. 130 ·No. 2 ·1977-05-00 ·Pages 577-82

Bagdasarian MM, Izakowska M, Bagdasarian M

Abstract

A class of mutations that confer resistance to rifampin in Salmonella typhimurium and Escherichia coli also suppresses the thermosensitivity of chromosome initiation in dnaA mutants. Ribonucleic acid polymerase is resistant to rifampin in vitro in these suppressive mutants, and the suppressors of dnaA cannot be separated from the rpoB mutations by transduction. It is concluded, therefore, that certain rpoB mutations may suppress the DnaA phenotype.

MeSH Terms
DNA Replication DNA-Directed RNA Polymerases/analysis,genetics Drug Resistance, Microbial Escherichia coli/genetics Genes Genes, Bacterial Mutation Rifampin/pharmacology Salmonella typhimurium/genetics Suppression, Genetic
Chemicals
DNA-Directed RNA Polymerases Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bagdasarian M M
Izakowska M
Bagdasarian M
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24 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.130.2.577-582.1977
Published
1977-05-00
Pages
577-82
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235255
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.130.2.577-582.1977 PMC Full Text View journal details
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