Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.

British journal of clinical pharmacology ·Vol. 19 Suppl 2 ·1985-00-00 ·Pages 203S-206S

John VA, Shotton PA, Moppert J, Theobald W

Abstract

Transit times for oxprenolol and metoprolol Oros drug delivery systems through the gastrointestinal tract have been measured in 35 individuals in six separate studies. A total of 45 systems were recovered in a median time of 27.4 h; individual transit times varied from 5.1 to 58.3 h. The residual amount of drug in recovered systems was inversely related to transit time and corresponded closely with the amount estimated from in vitro dissolution profiles.

MeSH Terms

Delayed-Action Preparations Digestive System/metabolism Humans Metoprolol/administration & dosage,metabolism Oxprenolol/administration & dosage,metabolism

Chemicals

Delayed-Action Preparations Oxprenolol Metoprolol

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

John V A

Shotton P A

Moppert J

Theobald W

References (8)

8 references, click to expand

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Absorption and excretions studies on tetracycline.
J Pharmacol Exp Ther. 1959 Apr;125(4):287-94 PMID: 13642270
The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine.
J Clin Invest. 1977 Jun;59(6):1158-66 PMID: 864008
Influence of site of drug delivery on the systemic availability of metoprolol: comparison of intragastric infusion and 14/190 Oros administration.
Br J Clin Pharmacol. 1985;19 Suppl 2:219S-224S PMID: 4005126
Factors controlling colonic motility: colonic pressures and transit after meals in patients with total gastrectomy, pernicious anaemia or duodenal ulcer.
Gut. 1970 Feb;11(2):100-10 PMID: 5441877
Pharmacokinetic investigation of the absorption of oxprenolol from Oros delivery systems in healthy volunteers: comparison of in vivo and in vitro drug release.
Br J Clin Pharmacol. 1985;19 Suppl 2:163S-169S PMID: 4005118

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1985.tb02763.x

Published

1985-00-00

Pages

203S-206S

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1463756

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1985.tb02763.x PMC Full Text View journal details

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Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.

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