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题目:: Uptake of released mast cell granules by reticular cells of the rat lymph node.
作者:: Miyata(K),Takaya(K)
状态:: 发布时间1985-07-24 , 更新时间 2006-11-15
期刊:: Cell Tissue Res
摘要:: Granules released from mast cells were examined by electron microscopy in regional lymph nodes of rats after the injection of a large dose of horseradish peroxidase (HRP). Thirty minutes after the injection, a large number of mast-cell granules were present in sinuses, most of which adhered to the surfaces of reticular cells and some to macrophages. Two hours after the injection, a number of granules had been taken up by both reticular cells and macrophages. Reticular cells took up more granules than macrophages. Twenty-four hours after the injection, granules were scarce in both types of cells and in the extracellular space. Reticular cells surely participate in dealing with released mast-cell granules in the lymph node. Fibronectin bound to all mast-cell granules was demonstrated by immunohistochemistry. Fibronectin probably enables negatively charged mast-cell granules to approach negatively charged cell surfaces to be taken up by both reticular cells and macrophages.
语言:: eng
DOI:

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