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PMID: 3994915 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chemopotentiation of CCNU metabolites by misonidazole.

British journal of cancer ·Vol. 51 ·No. 5 ·1985-05-00 ·Pages 733-5

Mulcahy RT

Abstract

暂无摘要

MeSH Terms

Animals Cell Survival/drug effects Cells, Cultured Dose-Response Relationship, Drug Drug Synergism Lomustine/pharmacology Misonidazole/pharmacology Nitroimidazoles/pharmacology

Chemicals

Nitroimidazoles Lomustine Misonidazole

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Mulcahy R T

References (11)

11 references, click to expand

The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds.
J Med Chem. 1967 Jul;10(4):668-74 PMID: 6037060
Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas.
Cancer Res. 1974 Jan;34(1):194-200 PMID: 4809457
Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.
Biochem Biophys Res Commun. 1974 Mar 25;57(2):426-33 PMID: 4151402
Hydroxylation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Biochem Pharmacol. 1975 Dec 1;24(23):2153-8 PMID: 1212264
Comparison of the properties of metabolites of CCNU.
Biochem Pharmacol. 1977 Dec 15;26(24):2331-6 PMID: 145865
Enhancement of nitrosourea cytotoxicity by misonidazole in vitro: correlation with carbamoylating potential.
Br J Cancer. 1984 Mar;49(3):307-13 PMID: 6704305
Effects of structure and chemical activity on the ability of nitrosoureas to inhibit DNA repair.
Cancer Res. 1980 Jan;40(1):50-5 PMID: 6444211
Chemical properties of nitrosoureas: implications for interaction with misonidazole.
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):599-602 PMID: 7107379
Potentiation of chemotherapy by hypoxic cell radiation sensitizers--a review.
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):1029-34 PMID: 7050050
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
Br J Cancer. 1983 May;47(5):659-69 PMID: 6849803
Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates.
Biochem Biophys Res Commun. 1978 Jul 28;83(2):754-62 PMID: 358985

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1985.110

Published

1985-05-00

Pages

733-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC1977066

Subset

Grants

NCI NIH HHS · CA-32374 · United States

External Links

PubMed source DOI: 10.1038/bjc.1985.110 PMC Full Text View journal details

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Chemopotentiation of CCNU metabolites by misonidazole.

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