Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens.

Pflugers Archiv : European journal of physiology ·Vol. 403 ·No. 1 ·1985-01-00 ·Pages 112-4

Wakui M, Inomata H

Abstract

The effects of exogenously applied adenosine triphosphate (ATP) on the smooth muscle of guinea-pig vas deferens were studied with the double sucrose-gap method. ATP evoked a membrane depolarization which was associated with a decrease in the size of electrotonic potentials. Conditioning hyperpolarization induced by current application caused an increase in the magnitude of the ATP-induced depolarization; the larger the conditioning hyperpolarization, the greater the ATP-induced depolarization. These results are discussed with respect to the ionic mechanism of the electrical event in response to ATP in this tissue.

MeSH Terms

Adenosine Triphosphate/pharmacology Animals Dose-Response Relationship, Drug Electric Conductivity Guinea Pigs Male Membrane Potentials/drug effects Membranes/drug effects Vas Deferens/drug effects

Chemicals

Adenosine Triphosphate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wakui M

Inomata H

References (8)

8 references, click to expand

Current spread in the smooth muscle of the guinea-pig vas deferens.
J Physiol. 1967 Mar;189(1):163-76 PMID: 16992243
Electrical responses of smooth muscle cells of the mouse uterus to adenosine triphosphate.
J Physiol. 1983 Sep;342:499-515 PMID: 6631746
Comparison of the effects of arylazido aminopropionyl ATP (ANAPP3), an ATP antagonist, on responses of the smooth muscle of the guinea-pig vas deferens to ATP and related nucleotides.
Eur J Pharmacol. 1982 Dec 3;85(3-4):277-90 PMID: 6295784
The effect of intracellular current pulses in smooth muscle cells of the guinea pig vas deferens at rest and during transmission.
J Gen Physiol. 1967 Nov;50(10):2459-75 PMID: 4294199
A comparison of the effects of adenosine triphosphate with noradrenaline and with the inhibitory potential of the guinea-pig taenia coli.
J Physiol. 1973 May;231(1):167-77 PMID: 4351785
The nature of non-cholinergic, non-adrenergic transmission in longitudinal and circular muscles of the guinea-pig ileum.
J Physiol. 1982 Nov;332:375-91 PMID: 6296375
Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist.
Science. 1980 Jun 13;208(4449):1273-6 PMID: 6103581
Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens.
J Physiol. 1984 Feb;347:561-80 PMID: 6142947

Article Info

Journal

Pflugers Archiv : European journal of physiology

Abbr.

Pflugers Arch

ISSN

0031-6768

DOI

10.1007/BF00583291

Published

1985-01-00

Pages

112-4

Language

English

Region

Germany

NLM ID

0154720

Subset

External Links

PubMed source DOI: 10.1007/BF00583291 View journal details

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Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens.

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