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PMID: 3973974 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor.

Journal of virology ·Vol. 54 ·No. 1 ·1985-04-00 ·Pages 1-6

Hiebert SW, Paterson RG, Lamb RA

Abstract

The nucleotide sequence of a cloned cDNA copy of the mRNA coding for the hemagglutinin-neuraminidase of the paramyxovirus SV5 was determined. There was a single large open reading frame on the mRNA which encoded a protein of 565 amino acids with a molecular weight of 62,134. The deduced amino acid sequence indicated that the only major hydrophobic region in the protein sufficiently long to anchor the protein in the membrane is located near the N terminus (amino acids 18 to 36). It is suggested that, like the influenza virus neuraminidase, hemagglutinin-neuraminidase of paramyxoviruses is oriented with its N terminus inserted into the membrane.

MeSH Terms
Amino Acid Sequence Base Sequence Hemagglutinins, Viral/genetics Membrane Proteins/genetics Neuraminidase/genetics Paramyxoviridae/genetics RNA, Messenger/genetics Solubility Viral Proteins/genetics
Chemicals
Hemagglutinins, Viral Membrane Proteins RNA, Messenger Viral Proteins Neuraminidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hiebert S W
Paterson R G
Lamb R A
References (27)
27 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.1.1-6.1985
Published
1985-04-00
Pages
1-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254752
Subset
IM
Grants
NIAID NIH HHS · AI-20201 · United States
Databases
GENBANK
K02870
External Links
PubMed source DOI: 10.1128/JVI.54.1.1-6.1985 PMC Full Text View journal details
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