Home LiteratureArticle Details

PMID: 3963258 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

The American journal of psychiatry ·Vol. 143 ·No. 5 ·1986-05-00 ·Pages 650-1

Arana GW, Goff DC, Friedman H, Ornsteen M, Greenblatt DJ, Black B, Shader RI

Abstract

Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.

MeSH Terms

Acute Disease Adult Aged Carbamazepine/adverse effects,therapeutic use Chromatography, Gas Depression, Chemical Drug Therapy, Combination Haloperidol/blood,therapeutic use Humans Male Middle Aged Psychiatric Status Rating Scales Psychotic Disorders/blood,drug therapy,psychology

Chemicals

Carbamazepine Haloperidol

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Arana G W

Goff D C

Friedman H

Ornsteen M

Greenblatt D J

Black B

Shader R I

Article Info

Journal

The American journal of psychiatry

Abbr.

Am J Psychiatry

ISSN

0002-953X

DOI

10.1176/ajp.143.5.650

Published

1986-05-00

Pages

650-1

Language

English

Region

United States

NLM ID

0370512

Subset

Grants

NIMH NIH HHS · MH-34223 · United States

External Links

PubMed source DOI: 10.1176/ajp.143.5.650 View journal details

Analysis Services

Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

Contact

WeChat Official Account