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PMID: 3960707 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Barium can replace calcium in calmodulin-dependent contractions of skinned renal arteries of the rabbit.

Pflugers Archiv : European journal of physiology ·Vol. 406 ·No. 3 ·1986-03-00 ·Pages 308-11

Kreye VA, Hofmann F, Mühleisen M

Abstract

Renal arteries of the rabbit were chemically skinned using Triton X-100. In EGTA-buffered solutions containing calmodulin and ATP, small strips of the skinned preparations were found to develop contractile force which was dependent on the concentrations of either free calcium or of free barium. However, a 220 times greater concentration of barium than of calcium was necessary for comparable effects. Quantitatively, the response to barium was dependent on the concentration of calmodulin added to the test solutions. The contractile effect of barium was partly antagonized by the calmodulin antagonist, trifluoperazine.

MeSH Terms
Animals Barium/metabolism Calcium/metabolism Calmodulin/antagonists & inhibitors,pharmacology,physiology Dose-Response Relationship, Drug In Vitro Techniques Muscle Contraction/drug effects Muscle, Smooth, Vascular/metabolism Rabbits Renal Artery/physiology Trifluoperazine/pharmacology
Chemicals
Calmodulin Trifluoperazine Barium Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kreye V A
Hofmann F
Mühleisen M
References (9)
9 references, click to expand
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00640919
Published
1986-03-00
Pages
308-11
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00640919 View journal details
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