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PMID: 3957856 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children.

Journal of autism and developmental disorders ·Vol. 16 ·No. 1 ·1986-03-00 ·Pages 23-9

Garnier C, Comoy E, Barthelemy C, Leddet I, Garreau B, Muh JP, Lelord G

Abstract

In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.

MeSH Terms
Age Factors Autistic Disorder/blood,urine Brain Chemistry Catecholamines/metabolism Child Child, Preschool Dopamine beta-Hydroxylase/blood Female Homovanillic Acid/urine Humans Male
Chemicals
Catecholamines Dopamine beta-Hydroxylase Homovanillic Acid
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Garnier C
Comoy E
Barthelemy C
Leddet I
Garreau B
Muh J P
Lelord G
References (21)
21 references, click to expand
  1. [Disturbances in dopamine metabolism in autistic children: results of clinical tests and urinary dosages of homovanilic acid (HVA)].
    Acta Psychiatr Belg. 1980 May-Jun;80(3):249-65 PMID: 6111177
  2. 6-Hydroxydopamine lesions of dopaminergic A10 neurons. Long-term effects on the urinary excretion of free and conjugated catecholamines and their metabolites in the rat.
    Brain Res. 1982 Mar 11;235(2):363-9 PMID: 6821353
  3. Decreased 24-hour urinary MHPG in childhood autism.
    Am J Psychiatry. 1979 Aug;136(8):1055-7 PMID: 464131
  4. NIH conference. Dopamine- -hydroxylase. Basic and clinical studies.
    Ann Intern Med. 1976 Aug;85(2):211-23 PMID: 782312
  5. Decreased urinary free catecholamines in childhood autism.
    J Am Acad Child Psychiatry. 1978 Autumn;17(4):671-8 PMID: 744850
  6. Cerebrospinal fluid, plasma, and urinary MHPG in children.
    Life Sci. 1981 Jun 22;28(25):2837-45 PMID: 6943404
  7. [Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)].
    Rev Neurol (Paris). 1978 Dec;134(12):797-801 PMID: 754238
  8. Contribution of plasma homovanillic acid (HVA) to urine and cerebrospinal fluid HVA in the monkey and its pharmacokinetic disposition.
    Life Sci. 1978 Dec 4;23(23):2339-47 PMID: 104110
  9. A rapid and simple gas-liquid chromatographic procedure for homovanillic and vanillylmandelic acid in urine.
    Clin Chim Acta. 1974 Nov 8;56(3):261-4 PMID: 4423410
  10. Gas chromatographic determination of urinary vanilglycolic acid, vanilglycol, vanilacetic acid and vanillactic acid-chemical parameters for the diagnosis of neurogenic tumours and the evaluation of their treatment.
    Clin Chim Acta. 1976 Oct 1;72(1):49-68 PMID: 184988
  11. 3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo.
    Science. 1979 Sep 7;205(4410):1025-7 PMID: 472724
  12. Serum dopamine-beta-hydroxylase levels in Down's syndrome.
    Clin Genet. 1974;5(4):312-5 PMID: 4277651
  13. A simple and sensitive assay for dopamine-beta-hydroxylase activity by dual-wavelength spectrophotometry.
    Biochem Med. 1974 Aug;10(4):320-8 PMID: 4604037
  14. The effects of haloperidol on learning and behavior in autistic children.
    J Autism Dev Disord. 1982 Jun;12(2):167-75 PMID: 7174605
  15. Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism.
    Arch Gen Psychiatry. 1977 May;34(5):553-6 PMID: 558741
  16. Clinical neurochemistry of autism and associated disorders.
    J Autism Dev Disord. 1982 Jun;12(2):147-65 PMID: 6184361
  17. Serum dopamine-beta-hydroxylase activity: clinical applications in child psychiatry.
    J Autism Dev Disord. 1980 Mar;10(1):1-14 PMID: 6085951
  18. Effects of pyridoxine and magnesium on autistic symptoms--initial observations.
    J Autism Dev Disord. 1981 Jun;11(2):219-30 PMID: 6765503
  19. Assessment of brain function in clinical pediatric research: behavioral and biological strategies.
    Schizophr Bull. 1982;8(2):205-35 PMID: 6180470
  20. Dopamine and serotonin metabolism in neuropsychiatrically disturbed children. CSF homovanillic acid and 5-hydroxyindoleacetic acid.
    Arch Gen Psychiatry. 1977 May;34(5):545-50 PMID: 860891
  21. Plasma dopamine-beta-hydroxylase in childhood psychosis.
    J Autism Child Schizophr. 1978 Sep;8(3):293-8 PMID: 211113
Article Info
Journal
Journal of autism and developmental disorders
Abbr.
J Autism Dev Disord
ISSN
0162-3257
DOI
10.1007/BF01531575
Published
1986-03-00
Pages
23-9
Language
English
Region
United States
NLM ID
7904301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01531575 View journal details
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