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PMID: 3957430 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hormonal influence on experimental infections by a toxic shock strain of Staphylococcus aureus.

Infection and immunity ·Vol. 52 ·No. 1 ·1986-04-00 ·Pages 331-3

Best GK, Abney TO, Kling JM, Kirkland JJ, Scott DF

Abstract

Subcutaneous infection chambers in rabbits were infected with a strain of Staphylococcus aureus isolated from a patient with toxic shock syndrome. Estrogens (mestranol and 17-beta-estradiol) protected male rabbits and prolonged survival. Neither androgens (testosterone and dihydrotestosterone) nor progesterone affected the susceptibility of intact or ovarihysterectomized female rabbits.

MeSH Terms

Animals Bacterial Toxins Enterotoxins/toxicity Estradiol/pharmacology Female Gonadal Steroid Hormones/pharmacology Male Mestranol/pharmacology Orchiectomy Ovariectomy Progesterone/blood Rabbits Staphylococcus aureus/pathogenicity Superantigens Testosterone/blood

Chemicals

Bacterial Toxins Enterotoxins Gonadal Steroid Hormones Superantigens enterotoxin F, Staphylococcal Testosterone Progesterone Estradiol Mestranol

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Best G K

Abney T O

Kling J M

Kirkland J J

Scott D F

References (14)

14 references, click to expand

Staphylococcus aureus isolates from patients with nonmenstrual toxic shock syndrome. Evidence for additional toxins.
JAMA. 1985 May 3;253(17):2538-42 PMID: 3981783
The influence of various hormones on the reticulo-endothelial system: endocrine control of body defense.
J Endocrinol. 1965 Nov;33(3):365-83 PMID: 4284824
Enhancement of staphylococcal infection in mice by estrogens. I. Effect of the timing, quantity and quality of the hormone.
Ann Med Exp Biol Fenn. 1967;45(2):138-46 PMID: 6049270
Depletion of the cytoplasmic estrogen receptor in gonadotropin-desensitized testes.
Endocrinology. 1980 Nov;107(5):1620-6 PMID: 7428683
Testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) in plasma of rabbit from birth to adulthood. Correlation with sexual and behavioural development.
Acta Endocrinol (Copenh). 1982 Mar;99(3):459-65 PMID: 6803487
Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin type C.
Infect Immun. 1982 Apr;36(1):123-8 PMID: 7042568
Effect of toxic shock syndrome toxin 1 on chicken embryos.
Infect Immun. 1985 Mar;47(3):710-2 PMID: 3972449
Characterization of Staphylococcus aureus isolates from patients with toxic shock syndrome, using polyethylene infection chambers in rabbits.
Infect Immun. 1983 Jan;39(1):383-7 PMID: 6822419
A rabbit model of toxic shock syndrome: clinicopathological features.
J Infect. 1984 May;8(3):205-11 PMID: 6234367
Influence of steroidal and nonsteroidal sex hormones on host resistance in mice: increased susceptibility to Listeria monocytogenes after exposure to estrogenic hormones.
Infect Immun. 1984 Nov;46(2):301-7 PMID: 6500690
Toxicity of staphylococcal toxic shock syndrome toxin 1 in rabbits.
Infect Immun. 1984 Nov;46(2):314-7 PMID: 6500691
Enhanced susceptibility of male rabbits to infection with a toxic shock strain of Staphylococcus aureus.
Infect Immun. 1984 Dec;46(3):727-32 PMID: 6500708
Acquired ability of Staphylococcus aureus to produce toxic shock-associated protein and resulting illness in a rabbit model.
Infect Immun. 1985 Mar;47(3):598-604 PMID: 3156093
Effect of estradiol on chlamydial genital infection of female guinea pigs.
Infect Immun. 1982 Nov;38(2):699-705 PMID: 7141709

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.52.1.331-333.1986

Published

1986-04-00

Pages

331-3

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC262240

Subset

External Links

PubMed source DOI: 10.1128/iai.52.1.331-333.1986 PMC Full Text View journal details

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Hormonal influence on experimental infections by a toxic shock strain of Staphylococcus aureus.

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