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PMID: 3956737 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Phosphorylation of 3-O-methyl-D-glucose by yeast and beef hexokinase.

FEBS letters ·Vol. 198 ·No. 2 ·1986-03-31 ·Pages 292-4

Malaisse-Lagae F, Giroix MH, Sener A, Malaisse WJ

Abstract

Beef heart hexokinase and yeast hexokinase both catalyzed the phosphorylation of 3-O-[14C]methyl-D-glucose. The maximal velocity was 3 orders of magnitude lower and the Km for the glucose analogue 40-120-times higher than those observed with D-[U-14C]glucose. Hence, 3-O-methyl-D-glucose should not be considered as a truly nonmetabolized analogue of D-glucose.

MeSH Terms

3-O-Methylglucose Animals Carbon Radioisotopes Cattle Glucose/metabolism Hexokinase/pharmacology Kinetics Methylglucosides/metabolism Methylglycosides/metabolism Phosphorylation Yeasts/enzymology

Chemicals

Carbon Radioisotopes Methylglucosides Methylglycosides 3-O-Methylglucose Hexokinase Glucose

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Malaisse-Lagae F

Giroix M H

Sener A

Malaisse W J

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(86)80423-9

Published

1986-03-31

Pages

292-4

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(86)80423-9 View journal details

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Phosphorylation of 3-O-methyl-D-glucose by yeast and beef hexokinase.

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