Home LiteratureArticle Details
PMID: 3934321 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

T cell receptor beta chain gene rearrangements in lymphoproliferative disorders of large granular lymphocytes/natural killer cells.

The Journal of experimental medicine ·Vol. 162 ·No. 6 ·1985-12-01 ·Pages 2156-62

Rambaldi A, Pelicci PG, Allavena P, Knowles DM, Rossini S, Bassan R, Barbui T, Dalla-Favera R, Mantovani A

Abstract

Twelve cases of T gamma LPD (lymphoproliferative disorders of Fc gamma receptor-bearing T cells) involving an expansion of large granular lymphocyte/natural killer (LGL/NK) cells were investigated for the expression of LGL/NK-associated markers and for T beta gene rearrangement. All the cases selected were classified as T gamma LPD on the basis of morphology, function, and phenotype of the circulating cells. 10 to 12 cases displayed clonal rearrangements of the T beta locus and expression of the T3 antigen, whereas the 2 remaining cases displayed the germline configuration of the T beta gene and no expression of the T3 antigen. T8, Mol, B73.1, and N901 antigens were variably expressed among both T beta+T3+ and T beta-T3- T gamma LPD cases. We suggest that individual T gamma LPD cases represent the clonal expansion of cells frozen at different stages of differentiation/activation within an individual hematopoietic LGL/NK lineage.

MeSH Terms
Antigens, Differentiation, T-Lymphocyte Antigens, Surface/genetics Cytotoxicity, Immunologic Humans Killer Cells, Natural/immunology,metabolism Leukemia/genetics,immunology Lymphocytosis/genetics,immunology Lymphoproliferative Disorders/classification,genetics,immunology Nucleic Acid Hybridization Phenotype Receptors, Antigen, T-Cell/genetics T-Lymphocytes/classification,immunology,metabolism
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Surface Receptors, Antigen, T-Cell
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Rambaldi A
Pelicci P G
Allavena P
Knowles D M
Rossini S
Bassan R
Barbui T
Dalla-Favera R
Mantovani A
References (14)
14 references, click to expand
  1. A monoclonal antibody reactive with human peripheral blood monocytes.
    J Immunol. 1980 Apr;124(4):1943-8 PMID: 6988511
  2. Isolation of human NK cells by density gradient centrifugation.
    J Immunol Methods. 1980;36(3-4):285-91 PMID: 7430655
  3. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
    J Immunol. 1981 Sep;127(3):1024-9 PMID: 6790607
  4. Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.
    J Immunol. 1981 Nov;127(5):1852-6 PMID: 6975300
  5. Antibody-dependent and -independent cytotoxicity of human mononuclear phagocytes: defective stimulation of tumoricidal activity in milk macrophages.
    Clin Exp Immunol. 1982 Sep;49(3):701-8 PMID: 7172502
  6. Phenotypic and functional heterogeneity of human cloned natural killer cell lines.
    Nature. 1983 Jan 13;301(5896):158-60 PMID: 6823293
  7. Murine monoclonal antibodies as probes for the phenotypical, functional, and molecular analysis of a discrete peripheral blood lymphocyte population exerting natural killer activity in vitro.
    Hum Immunol. 1985 Oct;14(2):87-102 PMID: 2416719
  8. Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor.
    Nature. 1983 Jun 30;303(5920):808-10 PMID: 6191218
  9. Human natural killer cells: biologic and pathologic aspects.
    Lab Invest. 1984 May;50(5):489-513 PMID: 6201674
  10. Abnormal expansions of polyclonal large to small size granular lymphocytes: reactive or neoplastic process?
    Blood. 1984 Jun;63(6):1271-7 PMID: 6326893
  11. T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics.
    Blood. 1984 Dec;64(6):1146-58 PMID: 6238640
  12. Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.
    Cell. 1984 Dec;39(2 Pt 1):261-6 PMID: 6333925
  13. Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
    Science. 1985 Jun 28;228(4707):1540-3 PMID: 2409597
  14. Characterization of an antigen expressed by human natural killer cells.
    J Immunol. 1983 Jun;130(6):2947-51 PMID: 6574190
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.6.2156
Published
1985-12-01
Pages
2156-62
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187976
Subset
IM
Grants
PHS HHS · 37165-01 · United States
NEI NIH HHS · EY03357 · United States
NCI NIH HHS · P30CA-1687 · United States
External Links
PubMed source DOI: 10.1084/jem.162.6.2156 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2