Seventy-five cases of head and neck cancer except of maxillary sinus, 27 cases of mesopharyngeal cancer, 6 cases of oral cancer, 9 cases of thyroid cancer and 9 cases of the other cancer, were treated with this multi-disciplinary treatment and the results were evaluated in this series. An intraarterial infusion drug, 5-FU, was used mainly through the superficial temporal artery. The five year survival rate was 46.1% in mesopharyngeal cancer, 34.4% in oral cancer and 33.3% in thyroid cancer. The results were relatively satisfactory despite the advanced stage of the cancer. Intraarterial chemotherapy has been a common treatment for maxillary cancer but the indication of this treatment should be developed in advanced head and neck cancer with radiotherapy or surgical treatment as a part of multi-disciplinary treatment.