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PMID: 3932204 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Suppression of immune response to Listeria monocytogenes: mechanism(s) of immune complex suppression.

Infection and immunity ·Vol. 50 ·No. 2 ·1985-11-00 ·Pages 343-53

Virgin HW, Wittenberg GF, Bancroft GJ, Unanue ER

Abstract

We have investigated possible mechanisms underlying immune complex suppression of resistance to Listeria monocytogenes. Inhibition of resistance was found when immune complexes were formed in vivo in immune mice or in nonimmune mice adoptively transferred with specific antibody. Suppression was also found when nonimmune mice were injected with immune complexes preformed in vitro. We investigated the role of complement by decomplementing mice with cobra venom factor purified by high-pressure liquid chromatography. Complete depletion of serum C3 did not eliminate immune complex suppression of resistance to L. monocytogenes, suggesting that complement activation is not required for immune complex suppression. Infection-induced changes in the surface phenotype and functional properties of macrophages from normal and immune complex-suppressed mice were also investigated. Macrophage expression of both H-2K and Ia molecules increased during the response of normal mice to L. monocytogenes. However, these changes were not found in immune complex-suppressed mice. In contrast, membrane interleukin 1 expression was increased in macrophages from suppressed mice compared with macrophages from normal mice. Macrophages from L. monocytogenes-infected normal and immune complex-suppressed mice expressed cytotoxicity against tumor cells in vitro. We conclude that immune complexes do not inhibit resistance to L. monocytogenes by activation of complement or decreasing macrophage cytotoxic activity. Rather, defects in Ia expression by macrophages from suppressed mice might be one component responsible for immune complex suppression of resistance to L. monocytogenes.

MeSH Terms
Animals Antigen-Antibody Complex/immunology Cell Adhesion Complement C3/analysis Cytotoxicity, Immunologic Elapid Venoms/isolation & purification Immunosuppression Therapy Interleukin-1/analysis Listeria monocytogenes/immunology Listeriosis/immunology Macrophages/immunology Membrane Proteins/analysis Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred CBA T-Lymphocytes/immunology
Chemicals
Antigen-Antibody Complex Complement C3 Elapid Venoms Interleukin-1 Membrane Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Virgin H W
Wittenberg G F
Bancroft G J
Unanue E R
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.50.2.343-353.1985
Published
1985-11-00
Pages
343-53
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC261955
Subset
IM
Grants
NIAID NIH HHS · AI 14732 · United States
NIAID NIH HHS · AI 22609 · United States
NCPDCID CDC HHS · NCI 14723 · United States
External Links
PubMed source DOI: 10.1128/iai.50.2.343-353.1985 PMC Full Text View journal details
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