Abstract
Fourteen polyene antibiotics and six of their semisynthetic derivatives were compared for their effects on potassium (K(+)) leakage and lethality or hemolysis of either Saccharomyces cerevisiae or mouse erythrocytes. These polyene antibiotics fell into two groups. Group I antibiotics caused K(+) leakage and cell death or hemolysis at the same concentrations of added polyene. In this group fungistatic and fungicidal levels were indistinguishable. Group I drugs included one triene (trienin); tetraenes (pimaricin and etruscomycin); pentaenes (filipin and chainin); one hexaene (dermostatin); and one polyene antibiotic with unknown chemical structure (lymphosarcin). Group II antibiotics caused considerable K(+) leakage at low concentrations and cell death or hemolysis at high concentrations. The fungistatic levels were clearly separable from fungicidal. This group included the heptaenes (amphotericin B, candicidin, aureofungin A and B, hamycin A and B), and five of their semisynthetic derivatives (amphotericin B methyl ester, N-acetyl-amphotericin B, hamycin A and B methyl esters, and N-acetyl-candicidin). Nystatin, classified as a tetraene, and its derivative, N-acetyl nystatin, also were in this group.
MeSH Terms
Animals
Antifungal Agents/classification,pharmacology
Chemical Phenomena
Chemistry
Erythrocytes/drug effects
In Vitro Techniques
Mice
Polyenes/classification,pharmacology
Potassium/metabolism
Saccharomyces cerevisiae/drug effects
Structure-Activity Relationship
Chemicals
Antifungal Agents
Polyenes
Potassium
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Kotler-Brajtburg J
Medoff G
Kobayashi G S
Boggs S
Schlessinger D
Pandey R C
Rinehart K L
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