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PMID: 3925068 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

The Journal of experimental medicine ·Vol. 162 ·No. 1 ·1985-07-01 ·Pages 358-62

Kirkman RL, Barrett LV, Gaulton GN, Kelley VE, Ythier A, Strom TB

Abstract

Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.

MeSH Terms
Animals Antibodies, Monoclonal/administration & dosage,immunology Graft Survival Heart Transplantation Immunosuppression Therapy Male Mice Mice, Inbred Strains Receptors, Immunologic/immunology Receptors, Interleukin-2 T-Lymphocytes/immunology Time Factors Transplantation, Homologous
Chemicals
Antibodies, Monoclonal Receptors, Immunologic Receptors, Interleukin-2
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kirkman R L
Barrett L V
Gaulton G N
Kelley V E
Ythier A
Strom T B
References (14)
14 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.1.358
Published
1985-07-01
Pages
358-62
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187689
Subset
IM
Grants
NIADDK NIH HHS · AM33040 · United States
NIADDK NIH HHS · AM33921 · United States
NIADDK NIH HHS · AM35929 · United States
External Links
PubMed source DOI: 10.1084/jem.162.1.358 PMC Full Text View journal details
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