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PMID: 3924529 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

DNA sequence of a 3.8 kilobase pair region controlling Drosophila chorion gene amplification.

Chromosoma ·Vol. 92 ·No. 2 ·1985-00-00 ·Pages 136-42

Levine J, Spradling A

Abstract

During Drosophila oogenesis, two clusters of chorion genes and their flanking DNA sequences undergo amplification in the ovarian follicle cells. Amplification results from repeated rounds of initiation and bidirectional replication within the chorion gene regions, possibly from a single origin, producing nested replication forks. Previously we have shown that following reintroduction into the Drosophila genome, a specific 3.8 kilobase pair DNA segment from the amplified third chromosome domain could induce developmentally regulated amplification at its site of insertion. Here we present the complete nucleotide sequence of this "amplification control element" and of genes encoding the chorion structural proteins s18-1 and s15-1, which are contained within it. Sequences that may be involved in the regulation of chorion gene amplification and expression are identified.

MeSH Terms
Animals Base Composition Base Sequence Cloning, Molecular DNA/metabolism Drosophila melanogaster/genetics Egg Proteins/genetics Female Gene Amplification Genes Nucleic Acid Hybridization Oogenesis
Chemicals
Egg Proteins chorion proteins DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Levine J
Spradling A
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Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/BF00328465
Published
1985-00-00
Pages
136-42
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
Databases
GENBANK
X06257
External Links
PubMed source DOI: 10.1007/BF00328465 View journal details
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