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PMID: 3920959 Published · ppublish English Journal Article

Activities of new quinoline derivatives against genital pathogens.

Antimicrobial agents and chemotherapy ·Vol. 27 ·No. 1 ·1985-01-00 ·Pages 76-8

Aznar J, Caballero MC, Lozano MC, de Miguel C, Palomares JC, Perea EJ

Abstract

The in vitro activities of four quinoline carboxylic acids against 48 strains of Neisseria gonorrhoeae, 10 of Chlamydia trachomatis, and 32 of Ureaplasma urealyticum were compared. Ciprofloxacin was the most active against N. gonorrhoeae and C. trachomatis but had poor bactericidal activity against U. urealyticum, whereas ofloxacin showed the most bactericidal activity against U. urealyticum but was less active than ciprofloxacin against the two former pathogens. Norfloxacin and enoxacin were less active against all the studied pathogens.

MeSH Terms
Anti-Bacterial Agents/pharmacology Chlamydia trachomatis/drug effects Doxycycline/pharmacology Female Genital Diseases, Female/microbiology Genital Diseases, Male/microbiology Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Quinolines/pharmacology Ureaplasma/drug effects
Chemicals
Anti-Bacterial Agents Quinolines Doxycycline
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Aznar J
Caballero M C
Lozano M C
de Miguel C
Palomares J C
Perea E J
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21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.27.1.76
Published
1985-01-00
Pages
76-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC176208
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.27.1.76 PMC Full Text View journal details
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