Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.

Parasitology ·Vol. 90 ( Pt 1) ·1985-02-00 ·Pages 45-55

Hudson AT, Randall AW, Fry M, Ginger CD, Hill B, Latter VS, McHardy N, Williams RB

Abstract

Novel hydroxynaphthoquinones are reported with outstanding efficacy against Plasmodium, Eimeria and Theileria species. Biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.

MeSH Terms

Animals Antiprotozoal Agents/pharmacology,therapeutic use Apicomplexa/drug effects Cattle Chickens/parasitology Coccidiosis/drug therapy Eimeria/drug effects Malaria/drug therapy Mice Naphthoquinones/pharmacology,therapeutic use Plasmodium berghei/drug effects Plasmodium falciparum/drug effects Protozoan Infections/drug therapy Theileriasis/drug therapy Toxoplasma/drug effects Toxoplasmosis, Animal/drug therapy

Chemicals

Antiprotozoal Agents Naphthoquinones

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Hudson A T

Randall A W

Fry M

Ginger C D

Hill B

Latter V S

McHardy N

Williams R B

Article Info

Journal

Parasitology

Abbr.

Parasitology

ISSN

0031-1820

DOI

10.1017/s0031182000049003

Published

1985-02-00

Pages

45-55

Language

English

Region

England

NLM ID

0401121

Subset

External Links

PubMed source DOI: 10.1017/s0031182000049003 View journal details

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Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.

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