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PMID: 3918819 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunohistochemical localization of cells reacting with monoclonal antibodies directed against the interleukin-2 receptor of murine, rat and human origin.

Clinical and experimental immunology ·Vol. 59 ·No. 1 ·1985-01-00 ·Pages 37-44

Takacs L, Osawa H, Törö I, Diamantstein T

Abstract

Recently, species specific monoclonal antibodies, directed against the interleukin-2 (IL-2) receptor of murine, rat and human origin, have been produced. In this study we demonstrate with immunohistological methods that cells reacting with these antibodies are present in normal primary and secondary lymphatic organs. The cells are exclusively localized in T cell-dependent areas, and their number increased as a result of immunization.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Female Humans Immunologic Techniques Interleukin-2/immunology Lymph Nodes/immunology Lymphoid Tissue/cytology,immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Rats Rats, Inbred Lew Rats, Inbred Strains Receptors, Antigen, T-Cell/immunology Receptors, Immunologic/immunology Receptors, Interleukin-2 Spleen/immunology Thymus Gland/immunology

Chemicals

Antibodies, Monoclonal Interleukin-2 Receptors, Antigen, T-Cell Receptors, Immunologic Receptors, Interleukin-2

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Takacs L

Osawa H

Törö I

Diamantstein T

References (5)

5 references, click to expand

The characteristics of a monoclonal antibody that binds specifically to rat T lymphoblasts and inhibits IL 2 receptor functions.
J Immunol. 1983 Jan;130(1):51-5 PMID: 6401187
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.
Nature. 1982 Nov 18;300(5889):267-9 PMID: 6815536
Mitogenic effects of partially purified interleukin 2 on thymocyte subpopulations and spleen t cells of the mouse.
Eur J Immunol. 1980 Sep;10(9):702-7 PMID: 6968268
A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.
J Immunol. 1984 May;132(5):2445-50 PMID: 6425405
Transient expression of interleukin 2 receptors. Consequences for T cell growth.
J Exp Med. 1983 Dec 1;158(6):1895-911 PMID: 6606011

Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1985-01-00

Pages

37-44

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1577179

Subset

External Links

PubMed source PMC Full Text View journal details

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Immunohistochemical localization of cells reacting with monoclonal antibodies directed against the interleukin-2 receptor of murine, rat and human origin.

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