Pharmacokinetic overview of indomethacin and sustained-release indomethacin.

The American journal of medicine ·Vol. 79 ·No. 4C ·1985-10-25 ·Pages 3-12

Yeh KC

Abstract

Indomethacin has a moderately short half-life, usually requiring dosing twice a day or three times a day. A more convenient once or twice daily regimen is made possible with a sustained-release formulation. Following multiple-dose administration of either sustained-release indomethacin (Indocin SR) or conventional indomethacin, drug accumulation is low. Clinical studies indicate comparable safety and efficacy profiles between the two preparations. Pharmacokinetic information on both dosage forms is reviewed.

MeSH Terms

Absorption Administration, Oral Adult Aged Antacids/pharmacology Biological Availability Circadian Rhythm Delayed-Action Preparations Enterohepatic Circulation Fasting Food Half-Life Humans Indomethacin/blood,metabolism Kinetics Middle Aged Protein Binding Tissue Distribution

Chemicals

Antacids Delayed-Action Preparations Indomethacin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Yeh K C

Article Info

Journal

The American journal of medicine

Abbr.

Am J Med

ISSN

0002-9343

DOI

10.1016/0002-9343(85)90510-8

Published

1985-10-25

Pages

3-12

Language

English

Region

United States

NLM ID

0267200

Subset

External Links

PubMed source DOI: 10.1016/0002-9343(85)90510-8 View journal details

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Pharmacokinetic overview of indomethacin and sustained-release indomethacin.

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