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PMID: 389892 Published · ppublish English Journal Article

Complement-mediated unspecific binding of immunoglobulins to some endocrine cells.

Histochemistry ·Vol. 63 ·No. 1 ·1979-09-00 ·Pages 15-21

Buffa R, Crivelli O, Fiocca R, Fontana P, Solcia E

Abstract

Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.

MeSH Terms
Animals Complement System Proteins/metabolism Cricetinae Gastric Mucosa/metabolism Guinea Pigs Humans Immunoglobulins/metabolism Immunologic Techniques Islets of Langerhans/metabolism Protein Binding Rabbits Swine
Chemicals
Immunoglobulins Complement System Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Buffa R
Crivelli O
Fiocca R
Fontana P
Solcia E
References (21)
21 references, click to expand
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Article Info
Journal
Histochemistry
Abbr.
Histochemistry
ISSN
0301-5564
DOI
10.1007/BF00508008
Published
1979-09-00
Pages
15-21
Language
English
Region
Germany
NLM ID
0411300
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00508008
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