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PMID: 3896506 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transformation of sporozoites of Plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host.

Cell and tissue research ·Vol. 241 ·No. 2 ·1985-00-00 ·Pages 353-60

Meis JF, Verhave JP, Jap PH, Meuwissen JH

Abstract

Intrahepatocytic transformation in vivo of the rodent malaria sporozoite of Plasmodium berghei, into the young trophic exoerythrocytic tissue stage was studied by immunofluorescence, light- and electron microscopy. The first 20 h of intracellular life were involved entirely in dedifferentiation with limited proliferation of organelles. From about 20 h onwards nuclear division commenced, rough endoplasmic reticulum became markedly expanded, and mitochondria increased in numbers. However, remains of the sporozoite pellicle (i.e., inner membranes and subpellicular microtubules) persisted for at least 28 h, which correlates with the persisting reaction of young exoerythrocytic forms with antisporozoite antibodies. In general, the basic mechanism of transformation resembles that of the ookinete into oocyst and that of the merozoite into erythrocytic trophozoite.

MeSH Terms
Animals Fluorescent Antibody Technique Liver/parasitology,pathology,ultrastructure Microscopy, Electron Plasmodium berghei/cytology,growth & development,ultrastructure Rats Rats, Inbred Strains
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Meis J F
Verhave J P
Jap P H
Meuwissen J H
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29 references, click to expand
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00217180
Published
1985-00-00
Pages
353-60
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00217180 View journal details
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