Biological activities of laminin.

Journal of cellular biochemistry ·Vol. 27 ·No. 4 ·1985-00-00 ·Pages 317-25

Kleinman HK, Cannon FB, Laurie GW, Hassell JR, Aumailley M, Terranova VP, Martin GR, DuBois-Dalcq M

Abstract

Laminin is a multifunctional protein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, migration, and agglutination as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and the response varies depending on the cell. Because most differentiated cells are difficult to maintain in culture, laminin may be an important supplement in studies on cell differentiation in vitro.

MeSH Terms

Animals Basement Membrane/physiology Binding Sites Cell Adhesion Cell Differentiation Cell Division Cell Movement Cells/cytology Cells, Cultured Chemical Phenomena Chemistry Collagen/metabolism Extracellular Matrix/physiology Hemagglutination Heparin/metabolism Heparitin Sulfate/metabolism Laminin/physiology Macromolecular Substances Molecular Weight Neoplasm Metastasis Proteoglycans/metabolism

Chemicals

Laminin Macromolecular Substances Proteoglycans Heparin Collagen Heparitin Sulfate

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Kleinman H K

Cannon F B

Laurie G W

Hassell J R

Aumailley M

Terranova V P

Martin G R

DuBois-Dalcq M

Article Info

Journal

Journal of cellular biochemistry

Abbr.

J Cell Biochem

ISSN

0730-2312

DOI

10.1002/jcb.240270402

Published

1985-00-00

Pages

317-25

Language

English

Region

United States

NLM ID

8205768

Subset

External Links

PubMed source DOI: 10.1002/jcb.240270402 View journal details

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